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Home / Primary Antibodies / IHC Antibodies

Anti-SPTBN1 Antibody BHA11301904

SKU : BHA11301904

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Mfr.No.	BS3402
Alternative Names	SPTBN1 ; SPTB2 ; Fodrin beta chain ; Beta-II spectrin ; Spectrin, non-erythroid beta chain 1
Antigen	SPTBN1
Categories	Primary Antibodies
Chromosome Location	2p16.2
Clonality	polyclonal
Description	Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 650-700 of Human Spectrin β II.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q01082
Uniprot	Q01082
Weight	275 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Spectrin β II (M687) polyclonal antibody detects endogenous levels of Spectrin β II protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301904	BS3402	50µl	$190.44		Add to Cart
BHA11301904	BS3402	100µl	$294.44		Add to Cart

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