Cellular retinol-binding protein I ; CRBP1 ; CRBP2 ; RBP1 ; RBP2 ; RBP4 ; RBPC ; Retinol binding protein 1 ; Retinol binding protein 1 cellular ; Retinol binding protein 2 cellular
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic
Chromosome Location
10q23.33
Clonality
monoclonal
Description
Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein (RBP). Its epitope localizes between aa 74-182 of human RBP. This MAb recognizes reduced and carboxy-methylated RBP (RCM-RBP) as well as the circulatory RBP but not the native RBP, thereby suggesting that its epitope becomes accessible either on unfolding or upon binding of RBP to transthyretin (prealbumin). RBP is responsible for distributing retinol from the retinoid stores in the liver to the various target tissues. Once secreted into the blood with bound retinol, the vitamin carrier circulates complexed with transthyretin prior to vitamin delivery at the plasma membrane through a receptor-mediated mechanism.
Host
Mouse
Immunogen
Retinol binding protein purified from human plasma
Isotype
IgG1 Kappa
Positive Control
Liver or placenta
Reactivity
Human, Monkey, Goat, Rabbit, Rat, Mouse
Recombinant
FALSE
Regulatory
RUO
Swissprot
P02753; P09455; P50120
Uniprot
529571
Gene Id
5947;5948;5950
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., IF ; IHC-F
Dilution
IF
1-2μg/ml
IHC-F
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-Retinol Binding Protein-1 (RBP1) Antibody BHA10204657