Cellular retinol-binding protein I ; CRBP1 ; CRBP2 ; RBP1 ; RBP2 ; RBP4 ; RBPC ; Retinol binding protein 1 ; Retinol binding protein 1 cellular ; Retinol binding protein 2 cellular
Categories
Primary Antibodies
Cellular Localization
Cytoplasmic
Chromosome Location
10q23.33
Clonality
monoclonal
Description
This MAb recognizes an epitope within the 74-182 C-terminal sequence (11kD peptide fragment) of human serum Cellular Retinol Binding Protein 1 (CRBP 1), a single-chain glycoprotein belonging to the superfamily of hydrophobic molecule transporter proteins, which is responsible for transport of retinol (vitamin A1) from the liver to peripheral target tissues, like the eye, where it mediates the cellular uptake. CRBP 1 is synthesized by hepatic parenchymal cells where it becomes bound to its ligand retinol and is then released into the circulation, where it binds further to the protein transthyretin, to form a transporting complex, which is big enough not to be lost by filtration through the kidney glomeruli. It is detected in nearly all tissues with higher expression in adult ovary, pancreas, pituitary gland, adrenal gland, and fetal liver.
Host
Mouse
Immunogen
Retinol binding protein-1 purified from human plasma
Isotype
IgG1 Kappa
Positive Control
Hepatic or ovarian carcinoma
Reactivity
Human, Chimpanzee, Monkey, Goat, Rabbit, Rat, Mouse
Recombinant
FALSE
Regulatory
RUO
Swissprot
P02753; P09455; P50120
Uniprot
529571
Gene Id
5947;5948;5950
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., IF ; IHC-F
Dilution
IF
1-2μg/ml
IHC-F
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-Retinol Binding Protein-1 (RBP1) Antibody BHA10204651