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Home / Primary Antibodies / IHC Antibodies

Anti-RB1 Antibody BHA11302450

SKU : BHA11302450

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Mfr.No.	BS4166
Alternative Names	Retinoblastoma-associated protein ; p105-Rb ; pRb ; Rb ; pp110 ; RB1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	13q14.2
Clonality	polyclonal
Description	The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)-dependent kinase-mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human Rb around the phosphorylation site of Serine 807.
Modification	phospho-S807
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P06400
Uniprot	P06400
Weight	106 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-Rb (S807) polyclonal antibody detects endogenous levels of Rb protein only when phosphorylated at Ser807
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302450	BS4166	50µl	$199.33		Add to Cart
BHA11302450	BS4166	100µl	$314.89		Add to Cart

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