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Home / Primary Antibodies / IHC Antibodies

Anti-PTPN6 Antibody BHA11302453

SKU : BHA11302453

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Mfr.No.	BS4169
Alternative Names	Tyrosine-protein phosphatase non-receptor type 6 ; Hematopoietic cell protein-tyrosine phosphatase ; Protein-tyrosine phosphatase 1C ; PTP-1C ; Protein-tyrosine phosphatase SHP-1 ; SH-PTP1 ; PTPN6 ; HCP ; PTP1C
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	12p13.31
Clonality	polyclonal
Description	SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R β chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human SHP-1 around the phosphorylation site of Tyrosine 536.
Modification	phospho-Y536
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P29350
Uniprot	P29350
Weight	68 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-SHP-1 (Y536) polyclonal antibody detects endogenous levels of SHP-1 protein only when phosphorylated at Tyr536.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302453	BS4169	50µl	$199.33		Add to Cart
BHA11302453	BS4169	100µl	$314.89		Add to Cart

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