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Home / Primary Antibodies / Phospho Antibodies

Anti-PRKAA1 Antibody BHA11302309

SKU : BHA11302309

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Mfr.No.	BS4010
Alternative Names	5'-AMP-activated protein kinase catalytic subunit alpha-1 ; AMPK subunit alpha-1 ; Acetyl-CoA carboxylase kinase ; ACACA kinase ; Hydroxymethylglutaryl-CoA reductase kinase ; HMGCR kinase ; au-protein kinase PRKAA1 ; PRKAA1 ; AMPK1
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	5p13.1
Clonality	polyclonal
Description	AMPK is a heterotrimeric complex comprising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKα1 and AMPKα2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKβ1 encodes a 271 amino acid protein and human AMPKβ2 encodes a 272 amino acid protein. The human AMPKγ1 gene encodes a 331 amino acid protein. Human AMPKγ2 and AMPKγ3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human AMPKα1 around the phosphorylation site of Serine 486.
Modification	phospho-S486
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q13131
Uniprot	Q13131
Weight	63 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: p-AMPKα1 (S486) polyclonal antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at Ser486. The antibody does not cross-react with phosphorylated AMPKα2 or other related proteins.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302309	BS4010	50µl	$199.33		Add to Cart
BHA11302309	BS4010	100µl	$314.89		Add to Cart

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