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Home / Primary Antibodies / Polyclonal Antibodies

Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA Antibody Picoband®

SKU : BHA21000191

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Mfr.No.	PB9314, PB9314-10ug, PB9314-Biotin, PB9314-Cy3, PB9314-Dylight488, PB9314-Dylight550, PB9314-Dylight594, PB9314-FITC, PB9314-HRP, PB9314-APC, PB9314-PE, PB9314-iFluor647, PB9314-carrier-free
Alternative Names	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Background	Phosphatidylinositol-4,5-bisphosphate 3-kinase, also called PIK3CA, is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. PIK3CA gene is mapped to 3q26.32. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P andPtdIns(4,5)P2. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy. In addition to that, the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA Antibody Picoband® catalog # PB9314. Tested in Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns (4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3
Host	Rabbit
Immunogen Region	E.coli-derived human PIK3CA recombinant protein (Position: H936-N1068). Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.
Isotype	Rabbit IgG
Molecular Weight	124 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform;PI3-kinase subunit alpha;PI3K-alpha;PI3Kalpha;PtdIns-3-kinase subunit alpha;2.7.1.153;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;PtdIns-3-kinase subunit p110-alpha;p110alpha;Phosphoinositide-3-kinase catalytic alpha polypeptide;Serine/threonine protein kinase PIK3CA;2.7.11.1;PIK3CA;
Tissue Specificity	Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P42336
Gene Id	5290
Gene Name	PIK3CA
Sequence	Belongs to the PI3/PI4-kinase family.
Subcellular Location	Cytoplasm. Nucleus. Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1.Hiles I, Otsu M, Volinia S, Fry M, Gout I, Dhand R et al. (August 1992). "Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit". Cell 70 (3): 41929. 2.Ma Y, Wei S, Lin Y, Lung J, Chang T, Whang-Peng J et al. (May 2000). "PIK3CA as an oncogene in cervical cancer". Oncogene 19 (23): 273944. 3.Weigelt, B., Wae, P. H., Downward, J. PIK3CA mutation, but not PTEN loss of function, determines the sensitivity of breast cancer cells to mTOR inhibitory drugs. Oncogene 30: 3222-3233, 2011.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000191-1	PB9314	100 ug	-	$370		Add to Cart
BHA21000191-2	PB9314-10ug	10 ug	Sample	$99		Add to Cart
BHA21000191-3	PB9314-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000191-4	PB9314-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000191-5	PB9314-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000191-6	PB9314-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000191-7	PB9314-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000191-8	PB9314-FITC	100 ug	FITC	$570		Add to Cart
BHA21000191-9	PB9314-HRP	100 ug	HRP	$570		Add to Cart
BHA21000191-10	PB9314-APC	100 ug	APC	$670		Add to Cart
BHA21000191-11	PB9314-PE	100 ug	PE	$670		Add to Cart
BHA21000191-12	PB9314-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000191-13	PB9314-carrier-free	100 ug	carrier-free	$370		Add to Cart

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