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Home / Primary Antibodies / Phospho Antibodies

Anti-PGR Antibody BHA11302443

SKU : BHA11302443

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Mfr.No.	BS4158
Alternative Names	NR3C3 ; PGR ; PRGR ; Progesterone receptor
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	11q22.1
Clonality	polyclonal
Description	The effects of progesterone are mediated by two functionally different isoforms of the progesterone receptor, PR-A and PR-B, which are transcribed from distinct, estrogen inducible promoters within a single copy of the PR gene. The PR-A and PR-B proteins are 90 kDa and 118 kDa respectively; the first 164 amino acids of PR-B are absent in PR-A. Progesterone bound PR-A and PR-B have different transcription activation properties. Specifically, PR-B functions as a transcriptional activator in most cell and promoter contexts, while PR-A is transcriptionally inactive and functions as a strong ligand dependent transdominant repressor of steroid hormone receptor transcriptiona activity. An inhibitory domain (ID), which maps to the amino terminus of the receptor, exists within both PR isoforms.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human PR around the phosphorylation site of Serine 190.
Modification	phospho-S190
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P06401
Uniprot	P06401
Weight	90 kDa (PR-A); 118 kDa (PR-B)

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-Progesterone Receptor (S190) polyclonal antibody detects endogenous levels of Progesterone Receptor protein only when phosphorylated at Ser190.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302443	BS4158	50µl	$199.33		Add to Cart
BHA11302443	BS4158	100µl	$314.89		Add to Cart

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