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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MYC Antibody BHA11309142

SKU : BHA11309142

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Mfr.No.	MB8024
Alternative Names	Myc proto-oncogene protein ; Class E basic helix-loop-helix protein 39 ; bHLHe39 ; Proto-oncogene c-Myc ; Transcription factor p64 ; MYC ; BHLHE39
Categories	Primary Antibodies
Chromosome Location	8q24.21
Clonality	monoclonal
Description	Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior including proliferation, differentiation and apoptosis. These proteins share a common basic-helix-loop-helix leucine zipper (bHLH-ZIP) motif required for dimerization and DNA-binding. Max was originally discovered based on its ability to associate with c-Myc and found to be required for the ability of Myc to bind DNA and activate transcription. Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families. The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior. The Mad family consists of four related proteins; Mad1, Mad2 (Mxi1), Mad3 and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes such as proliferation, transformation and prevention of apoptosis by inhibiting transcription.
Host	Mouse
Immunogen	Synthetic peptide, corresponding Human Myc.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P01106
Uniprot	P01106
Weight	49, 51 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: Myc-tag mAb detects endogenous levels of Myc-tag protein.
Purity	The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:2000-1:10000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11309142	MB8024	50µl	$190.44		Add to Cart
BHA11309142	MB8024	100µl	$294.44		Add to Cart

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