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Home / Primary Antibodies / Monoclonal Antibodies

Anti-MLH1 Antibody BHA11309092

SKU : BHA11309092

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Mfr.No.	MB0151
Alternative Names	DNA mismatch repair protein Mlh1 ; MutL protein homolog 1 ; COCA2
Categories	Primary Antibodies
Chromosome Location	3p22.2
Clonality	monoclonal
Description	MLH1 is an integral part of the protein complex responsible for mismatch repair that is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas.
Host	Mouse
Immunogen	Recombinant full length Human MLH1.
Reactivity	Human
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P40692
Uniprot	P40692
Weight	Predicted band size:85KDaObserved band size:85KDa

Description	Product: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol Specificity: This antibody detects endogenous levels of MLH1 and does not cross-react with related proteins
Purity	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, ICC

Description

WB ; ICC

Dilution

WB	1:500-1000
ICC	1:50-200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11309092	MB0151	50µl	$234.89		Add to Cart
BHA11309092	MB0151	100µl	$368.22		Add to Cart

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