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Home / Primary Antibodies / IHC Antibodies

Anti-MCL1 Antibody BHA11308916

SKU : BHA11308916

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Mfr.No.	BS9891M
Alternative Names	Induced myeloid leukemia cell differentiation protein Mcl-1 ; Bcl-2-like protein 3 ; Bcl2-L-3 ; Bcl-2-related protein EAT/mcl1 ; mcl1/EAT ; MCL1 ; BCL2L3
Antigen	MCL1
Categories	Primary Antibodies
Chromosome Location	1q21.2
Clonality	monoclonal
Description	B cell CLL/lymphoma-2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia-1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase-3 (GSK-3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors PI 3-kinase and Akt. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.
Host	Rabbit
Immunogen	Recombinant antibody.
Reactivity	Human, Mouse, Rat
Recombinant	TRUE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q07820
Uniprot	Q07820
Weight	29, 37 kDa

Description	Product: Recombinant Rabbit Monoclonal Antibody. 1TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. Specificity:* This antibody detects endogenous levels of MCL1 and does not cross-react with related proteins.
Purity	Protein A affinity purified
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, ICC/IF, IHC, FC

Description

WB ; ICC/IF ; IHC ; FC

Dilution

WB	1:1,000
ICC/IF	1:50-1:200
IHC	1:50-1:200
FC	1:50-1:100

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11308916	BS9891M	50µl	$279.33		Add to Cart
BHA11308916	BS9891M	100µl	$403.78		Add to Cart

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