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Home / Primary Antibodies / IHC Antibodies

Anti-MAPK10/MAPK9/MAPK8 Antibody BHA11302691

SKU : BHA11302691

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Mfr.No.	BS4764
Alternative Names	JNK 46 ; JNK 55 ; JNK ; JNK1 ; JNK1A2 ; JNK2 ; JNK21B1/2 ; JNK2ALPHA ; JNK2B ; JNK2BETA ; JNK3 ; JNK3A ; MAP kinase 8 ; MAP kinase 9 ; MAP kinase p49 3F12 ; MAPK 8 ; MAPK 9 ; MAPK10 ; MAPK8 ; MAPK9 ; MGC50974 ; Mitogen activated protein kinase 10 ; Mitogen activated protein kinase 8 ; Mitogen activated protein kinase 9
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Tyrosine 185.
Modification	phospho-Y185
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P45983/P45984/P53779
Uniprot	P45983/P45984/P53779
Weight	46,54 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-JNK1/2/3 (Y185) polyclonal antibody detects endogenous levels of JNK1/2/3 protein only when phosphorylated at Tyr185.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC

Description

IHC

Dilution

IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302691	BS4764	50µl	$199.33		Add to Cart
BHA11302691	BS4764	100µl	$314.89		Add to Cart

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