Anti-MAP2K1/MAP2K2 Antibody BHA11308886

Mfr.No.	BS9855M
Alternative Names	Dual specificity mitogen-activated protein kinase kinase 1 ; MAP kinase kinase 1 ; MAPKK 1 ; MKK1 ; ERK activator kinase 1 ; MAPK/ERK kinase 1 ; MEK 1 ; MAP2K1 ; MEK-1 ; PRKMK1 ; Dual specificity mitogen-activated protein kinase kinase 2 ; MAP kinase kinase 2 ; MAPKK 2 ; ERK activator kinase 2 ; MAPK/ERK kinase 2 ; MEK 2 ; MAP2K2 ; MEK-2 ; MKK2 ; PRKMK2
Categories	Primary Antibodies
Clonality	monoclonal
Description	MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
Host	Rabbit
Immunogen	Recombinant antibody.
Reactivity	Human, Mouse, Rat, Zebra Fish
Recombinant	TRUE
Regulatory	RUO

Description	Product: Recombinant Rabbit Monoclonal Antibody. 1TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. Specificity:* This antibody detects endogenous levels of MEK1/2 and does not cross-react with related proteins.
Purity	Protein A affinity purified
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.