HLA-DP: HLA class II histocompatibility antigen DP alpha 1 chain ; HLA DP1A ; HLA SB alpha chain ; HLADP ; HLADPA1 ; HLASB ; HLASB histocompatibility type ; Human MHC class II HLA SB alpha ; Major histocompatibility complex class II DP alpha 1 ; MHC class II DP3 alpha
Categories
Primary Antibodies
Cellular Localization
Cell Surface
Chromosome Location
6p21.3 (HLA-DP ; HLA-DR)
Clonality
Monoclonal
Description
Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DR and DP. Human MHC class II antigens are transmembrane glycoproteins composed of an chain (36kDa) and a chain (27kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.
Host
Mouse
Immunogen
Human REH cells
Isotype
IgG3 Kappa
Positive Control
Raji cells. Tonsil or lymph node
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P04440; P01903
Uniprot
347270; 520048
Gene Id
3115;3122
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
FACS, IF, IHC-F
Description
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F
Dilution
FACS
0.5-1μg/million cells in 0.1ml
IF
0.5-1μg/ml
IHC-F
0.5-1μg/ml for 30 minutes at RT
Reviews of Anti-HLA-DP/-DR (MHC II) Antibody BHA10201828