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Home / Primary Antibodies / Phospho Antibodies

Anti-HDAC2 Antibody BHA11302594

SKU : BHA11302594

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Mfr.No.	BS4637
Alternative Names	Histone deacetylase 2 ; HD2 ; Name: HDAC 2
Categories	Primary Antibodies ; Phospho Antibodies
Chromosome Location	6q21
Clonality	polyclonal
Description	In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human HDAC2 around the phosphorylation site of Serine 394.
Modification	phospho-S394
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92769
Uniprot	Q92769
Weight	60 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-HDAC2 (S394) polyclonal antibody detects endogenous levels of HDAC2 protein only when phosphorylated at Ser394.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302594	BS4637	50µl	$199.33		Add to Cart
BHA11302594	BS4637	100µl	$314.89		Add to Cart

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