Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelo-suppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. The ability of HCC-4 to markedly improve recognition of poorly immunogenic cells suggests that it could be an effective component of antitumor vaccines.
Host
Mouse
Immunogen
Recombinant human HCC-4 protein
Isotype
IgG1 Kappa
Positive Control
Liver, spleen and thymus
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
O15467
Uniprot
10458
Gene Id
6360
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
ELISA, Func
Description
Optimal dilution for a specific application should be determined., ELISA ; Func
Dilution
ELISA
For coating, order Ab without BSA
Func
Order Ab without BSA & Azide
Reviews of Anti-HCC-4 / Liver Expressed Chemokine (LEC) Antibody BHA10204880