GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Host
Mouse
Immunogen
Recombinant human GP2 protein fragment (aa35-179) (exact sequence is proprietary)
Isotype
IgG2b Lambda
Positive Control
PANC-1 cells. Pancreas
Reactivity
Human
Recombinant
FALSE
Regulatory
RUO
Swissprot
P55259
Uniprot
53985
Gene Id
2813
Buffer
200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration
1.0mg/ml
Description
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Applications
ELISA, FACS, IF
Description
Optimal dilution for a specific application should be determined., ELISA ; FACS ; IF
Dilution
ELISA
For coating, order Ab without BSA
FACS
0.5-1μg/million cells
IF
0.5-1μg/ml
Reviews of Anti-GP2 (Glycoprotein 2) / ZAP75 Antibody BHA10201634