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Home / Primary Antibodies / IHC Antibodies

Anti-FOXO4/FOXO3/FOXO1 Antibody BHA11302528

SKU : BHA11302528

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Mfr.No.	BS4266
Alternative Names	Forkhead box protein O4 ; Fork head domain transcription factor AFX1 ; AFX ; AFX1 ; MLLT7 ; FOXO4 ; Forkhead box protein O1 ; Forkhead box protein O1A ; Forkhead in rhabdomyosarcoma ; FOXO1 ; FKHR ; FOXO1A ; Forkhead box protein O3 ; AF6q21 protein ; Forkhead in rhabdomyosarcoma-like 1 ; FOXO3 ; FKHRL1 ; FOXO3A
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors.FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
Host	Rabbit
Immunogen	Synthetic phosphopeptide derived from human FoxO1 around the phosphorylation site of Threonine 24.
Modification	phospho-T24/32
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q12778/O43524/P98177
Uniprot	Q12778/O43524/P98177
Weight	70 to 82 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: p-FoxO1/3/4 (T24/32) polyclonal antibody detects endogenous levels of FoxO1 protein only when phosphorylated at Thr24. This antibody also detects endogenous levels of FoxO3 and FoxO4 protein only when phosphorylated at Thr32.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11302528	BS4266	50µl	$199.33		Add to Cart
BHA11302528	BS4266	100µl	$314.89		Add to Cart

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