Anti-Filaggrin Antibody BHA10201116

Mfr.No.	2312-MSM2-P1ABX
Alternative Names	ATOD2 ; Epidermal Filaggrin ; Filaggrin ; Filaggrin precursor ; Fillagrin ; FLG ; Profilaggrin
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	1q21.3
Clonality	Monoclonal
Description	Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Host	Mouse
Immunogen	Recombinant human Filaggrin protein fragment (aa 998-1104) (exact sequence is proprietary)
Isotype	IgG1 Kappa
Positive Control	U-251-MG cells or Skin
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO

Swissprot	P20930
Uniprot	654510
Gene Id	2312

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration	1.0mg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Applications

FACS, IF, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined., FACS ; IF ; IHC-F

Dilution

FACS	0.5-1μg/million cells
IF	1-2μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201116	2312-MSM2-P1ABX	100µg	$393.20		Add to Cart

Anti-Filaggrin Antibody BHA10201116

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