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Home / Primary Antibodies / Conjugated Primary Antibodies

Anti-EGFR Antibody (EGFRY1068-E5) SureLight® 488 BHA10600048

SKU : BHA10600048

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Abwiz Bio Inc.

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Mfr.No.	2085
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	The epidermal growth factor (EGFR, phospho EGFR), also known as ErbB1 and HER1, is a receptor tyrosine kinase (RTK) and a known oncogenic driver of several cancer types including lung cancer (1), breast cancer (2), and glioblastoma (3) and inhibitors of EGFR have been the most successful examples of targeted therapies including antibody therapeutics (e.g. trastuzumab and cetuximab) as well as small-molecule inhibitors erlotinib and lapatinib (4). Ligand binding induces multiple EGFR auto-phosphorylation including Tyr1068. This phosphorylation recruits growth factor receptor-bound protein 2 (Grb2) which mediates downstream modulation of EGFR signaling including activation of signaling cascades through interaction of Grb2 SH3 domains with the Ras guanine exchange factor, son of sevenless homolog (SOS) or downregulation of phospho EGFR signaling through internalization and ubiquitination-targeted degradation (5).
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human phospho EGFR.
Isotype	IgG1 Kappa
Modification	phospho-Tyr1068
Reactivity	Mouse, Human
Reregulatory	RUO

Clone No	EGFRY1068-E5

Buffer	1X PBS, 0.09% NaN3, 0.2% BSA
Storage	2-8ºC

Applications	FACS
Description	FACS

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1 Reviews

Reviewed by Mithun Mathew Awesome product

Mithun Mathew,

3 Years ago

SKU	Supplier No.	Size	Your price	Quantity
BHA10600048	2085	100Tests	$320.67		Add to Cart
BHA10600048	2085	10Tests	$120.67		Add to Cart

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