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Home / Antibodies

Anti-DFFA Antibody BHA11304530

SKU : BHA11304530

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Mfr.No.	BS61762
Alternative Names	DNA fragmentation factor subunit alpha ; DNA fragmentation factor 45 kDa subunit ; DFF-45 ; Inhibitor of CAD ; ICAD ; DFFA ; DFF1 ; DFF45 ; H13
Antigen	DFFA
Categories	Primary Antibodies
Chromosome Location	1p36.22
Clonality	polyclonal
Description	Human DFF45 and its mouse homologue ICAD function in normal cells as chaperones for caspase-activated deoxyribonuclease (DFF40 or CAD) during its synthesis. The association of DFF45 (or its isoform DFF35) with DFF40 inhibits the DNAse activity of the latter. In vitro, DFF45 has been shown to be the target of several caspases, including caspase-3, -6, -7, -8 and granzyme B. In vivo, caspase-3 is believed to be the primary enzyme responsible for processing DFF45 and release of its carboxy-terminal fragment. The cleavage of DFF45 inactivates its inhibitory function on DFF40 and causes nuclear DNA degradation by DFF40, leading to cell death.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 200-250 of Human DFFA.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O00273
Uniprot	O00273
Weight	45 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: DFFA polyclonal antibody detects endogenous levels of DFFA protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304530	BS61762	50µl	$190.44		Add to Cart
BHA11304530	BS61762	100µl	$294.44		Add to Cart

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