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Home / Primary Antibodies / Polyclonal Antibodies

Anti-cIAP1/BIRC2 Antibody Picoband®

SKU : BHA21001545

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Mfr.No.	A01700-1, A01700-1-10ug, A01700-1-Biotin, A01700-1-Cy3, A01700-1-Dylight488, A01700-1-Dylight550, A01700-1-Dylight594, A01700-1-FITC, A01700-1-HRP, A01700-1-APC, A01700-1-PE, A01700-1-iFluor647, A01700-1-carrier-free
Alternative Names	baculoviral IAP repeat containing 2
Background	Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alteatively spliced transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-cIAP1/BIRC2 Antibody Picoband® catalog # A01700-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein
Host	Rabbit
Immunogen Region	E. coli-derived human cIAP1 recombinant protein (Position: D320-T570).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Baculoviral IAP repeat-containing protein 2
Tissue Specificity	Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q13490
Gene Id	329
Gene Name	BIRC2
Subcellular Location	Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Bertrand, M. J. M., Doiron, K., Labbe, K., Koeluk, R. G., Barker, P. A., Saleh, M. Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the patte recognition receptors NOD1 and NOD2. Immunity 30: 789-801, 2009.<br /><br />2. Dai, Z., Zhu, W.-G., Morrison, C. D., Brena, R. M., Smiraglia, D. J., Raval, A., Wu, Y.-Z., Rush, L. J., Ross, P., Molina, J. R., Otterson, G. A., Plass, C. A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Hum. Molec. Genet. 12: 791-801, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001545-1	A01700-1	100 ug	-	$370		Add to Cart
BHA21001545-2	A01700-1-10ug	10 ug	Sample	$99		Add to Cart
BHA21001545-3	A01700-1-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001545-4	A01700-1-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001545-5	A01700-1-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001545-6	A01700-1-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001545-7	A01700-1-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001545-8	A01700-1-FITC	100 ug	FITC	$570		Add to Cart
BHA21001545-9	A01700-1-HRP	100 ug	HRP	$570		Add to Cart
BHA21001545-10	A01700-1-APC	100 ug	APC	$670		Add to Cart
BHA21001545-11	A01700-1-PE	100 ug	PE	$670		Add to Cart
BHA21001545-12	A01700-1-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001545-13	A01700-1-carrier-free	100 ug	carrier-free	$370		Add to Cart

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