c-Myc is a phosphoprotein involved with cell proliferation and differentiation. It is a useful marker for differentiation between Burkitt's lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) since, despite morphological similarities between the two B-cell lymphomas, Anti-c-Myc stains all BL and only a few DLBCL cases. A panel of antibodies against c-Myc, CD10, BCL2, and Ki-67 is useful for cases where Myc FISH analysis is warranted or can be omitted. Nuclear c-Myc overexpression is common in luminal cells of prostate intraepithelial neoplasia, many primary carcinomas, and metastatic disease.
Host
Rabbit
Isotype
IgG
Species
Human
Clone No
IHC448
Buffer
Tris Buffer pH7.6 with BSA, and sodium azide as preservative