Anti-Blood Group Antigen Lewis B Antibody BHA10201371

Mfr.No.	2525-MSM1X-P0
Alternative Names	Blood group Lewis alpha-4-fucosyltransferase ; Fucosyltransferase 3 ; Fucosyltransferase III ; FucT-III ; FUT3 ; Galactoside 3(4)-L-fucosyltransferase ; gastric mucin ; leB ; lewis antigen system ; lewis B blood group antigen
Categories	Primary Antibodies
Cellular Localization	Cytoplasmic
Chromosome Location	19p13.3
Clonality	monoclonal
Description	The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Lewis blood group antigens are carbohydrate moieties structurally integrated in mucous secretions. Lewis antigen system alterations have been described in gastric carcinoma and associated lesions. Anomalous expression of Lewis B antigen has been found in some non-secretory gastric carcinomas and colorectal cancers.
Host	Mouse
Immunogen	Mucin isolated from a human ovarian cyst fluid
Isotype	IgG1 Kappa
Positive Control	Colon
Reactivity	Human, Guinea pig
Recombinant	FALSE
Regulatory	RUO

Swissprot	P21217
Uniprot	169238
Gene Id	2525

Buffer	200μg/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA; 0.05% azide. Also available WITHOUT BSA; azide at 1.0mg/ml.
Concentration	200µg/ml
Description	There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Purity	Purified Ab with BSA and Azide at 200μg/ml

Applications

IF, IHC-F

Description

(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined., IF ; IHC-F

Dilution

IF	0.5-1μg/ml
IHC-F	0.5-1μg/ml for 30 minutes at RT

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SKU	Supplier No.	Size	Your price	Quantity
BHA10201371	2525-MSM1X-P0	20µg	$204.67		Add to Cart
BHA10201371	2525-MSM1X-P0	100µg	$393.20		Add to Cart

Anti-Blood Group Antigen Lewis B Antibody BHA10201371

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