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Home / Primary Antibodies / Phospho Antibodies

Anti-4E-BP1 Antibody (4EB1T37T46-A5) Unconjugated BHA10600006

SKU : BHA10600006

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Abwiz Bio Inc.

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Mfr.No.	2041
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	monoclonal
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (PHAS-1, EIF4EBP1, eIF4E-binding protein 1, phospho 4E-BP1) is one member of a family of translation repressor proteins encoded by the EIF4EBP gene (1). The protein directly inhibits cap-dependent translation by binding eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multi-subunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation(2). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of phospho 4E-BP1 to eIF4E, it is thought to prime phospho 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.
Host	Rabbit
Immunogen	A synthetic phospho-peptide corresponding to residues surrounding Thr37/46 of human phospho 4E-BP1.
Isotype	IgG1 Kappa
Modification	Phospho-Thr37, Phospho-Thr46
Reactivity	Rat, Mouse, Human
Reregulatory	RUO

Clone No	4EB1T37T46-A5

Buffer	1X PBS, 0.02% NaN3, 50% Glycerol, 0.1% BSA
Concentration	0.5mg/ml
Dilutions	1.0 - 0.1 µg/ml
Storage	-20ºC

Applications	IHC, WB, FACS
Description	IHC ; WB ; FACS

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SKU	Supplier No.	Size	Your price	Quantity
BHA10600006	2041	200µl	$466.50		Add to Cart
BHA10600006	2041	20µl	$196.67		Add to Cart

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