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Tsc1-Flox

SKU : BHAM00331

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200231
Description	Model Description: These mice carry loxP sites flanking exon 17-18 of Tsc1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tsc1 gene. Official Symbol: Tsc1 NCBI ID: 64930 MGI ID: 1929183 Ensembl ID: ENSMUSG00000026812 Pubmed: Tsc1 Human Ortholog: TSC1
Nomenclature	C57BL/6JSmoc-Tsc1^{tm1(flox)Smoc}
Exon	Exon 17-18
Application	Research On Mtor Signal Transduction And Respiratory Electron Transport, Atp Synthesis Produced By Chemical Permeation Coupling, And Heat Produced By Protein Uncoupling
Disease	Tuberous Sclerosis
Disease	Nervous System Disease
KI/KO Gene	Tsc1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Syn1-cre mice.

Reference	MGI:4438921 Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ, Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci. 2008 May 21;28(21):5422-32

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