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Trp53-Flox

SKU : BHAM00336

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-18005
Description	Model Description: These Trp53 flox mice possess loxP sites flanking exons 5-7 . When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene. Click here for more information. Official Symbol: Trp53 NCBI ID: 22059 MGI ID: 98834 Ensembl ID: ENSMUSG00000059552 Pubmed: Trp53 Human Ortholog: TP53
Nomenclature	C57BL/6JSmoc-Trp53^{tm2(flox)Smoc}
Exon	Exon s
Application	Cancer Research
Disease	Medulloblastoma
Disease	Spontaneous Tumor
KI/KO Gene	Trp53
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Xrcc4-Flox(NM-CKO-2100799) and Nes-cre mice.
Synonyms	bbl, bfy, bhy, p44, p53, Tp53

Reference	Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW, XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83

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