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Smad4-Flox

SKU : BHAM00318

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-18011
Description	Model Description: These mice carry loxP sites flanking exon3-4 of Smad4 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Smad4 gene. Official Symbol: Smad4 NCBI ID: 17128 MGI ID: 894293 Ensembl ID: ENSMUSG00000024515 Pubmed: Smad4 Human Ortholog: SMAD4
Nomenclature	C57BL/6JSmoc-Smad4^{tm1(flox)Smoc}
Exon	Exon 3-4
Disease	Osteogenesis Imperfecta
Disease	Spontaneous Tumor
KI/KO Gene	Smad4
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Sp7-tTA,tetO-EGFP/cre mice.
Synonyms	DPC4; Madh4; AW743858; D18Wsu70e

Reference	MGI:2178041 Salazar VS, Zarkadis N, Huang L, Norris J, Grimston SK, Mbalaviele G, Civitelli R, Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype. J Cell Sci. 2013 Nov 1;126(Pt 21):4974-84

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