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Daam1-Flox

SKU : BHAM00062

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	TBD
Description	Model Description: These mice carry loxP sites flanking target exons of Daam1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Daam1 gene. Official Symbol: Daam1 NCBI ID: 208846 MGI ID: 1914596 Ensembl ID: ENSMUSG00000034574 Pubmed: Daam1 Human Ortholog: DAAM1
Nomenclature	C57BL/6JSmoc-Daam1^{em1(flox)Smoc}
Exon	Exon s
Disease	Intrinsic Cardiomyopathy
Disease	Cardio-metabolic Disease
KI/KO Gene	Daam1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nkx2-5-Cre mice.

Reference	MGI:4946226 Ajima R, Bisson JA, Helt JC, Nakaya MA, Habas R, Tessarollo L, He X, Morrisey EE, Yamaguchi TP, Cohen ED, DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39

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