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Ctnnb1-Flox

SKU : BHAM00067

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-200154
Description	Model Description: These mice carry loxP sites flanking exon 2-6 of Ctnnb1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Ctnnb1 gene. Official Symbol: Ctnnb1 NCBI ID: 12387 MGI ID: 88276 Ensembl ID: ENSMUSG00000006932 Pubmed: Ctnnb1 Human Ortholog: CTNNB1
Nomenclature	C57BL/6JSmoc-Ctnnb1^{em1(flox)Smoc}
Exon	Exon 2-6
Application	Microa And Cdk-Mediated Phosphorylation And Cdc6 Removal In Cardiomyocyte Hypertrophy
Disease	Autism Spectrum Disorder
Disease	Nervous System Disease
KI/KO Gene	Ctnnb1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pvalb-cre mice.
Synonyms	Bfc, Mesc, Catnb

Reference	MGI:3606731 Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y, Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects. Hum Mol Genet. 2016 Jul 1;25(13):2738-2751

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