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Brca1-Flox

SKU : BHAM00037

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Shanghai Model Organisms Center, Inc.

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Mfr.No.	NM-CKO-18007
Description	Model Description: These Brca1 flox mice possess loxP sites flanking exons 5 . When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene. Official Symbol: Brca1 NCBI ID: 12189 MGI ID: 104537 Ensembl ID: ENSMUSG00000017146 Pubmed: Brca1 Human Ortholog: BRCA1
Nomenclature	C57BL/6JSmoc-Brca1^tm1Smoc
Exon	Exon s
Application	Cancer Research
Disease	Breast Cancer
Disease	Spontaneous Tumor
KI/KO Gene	Brca1
Notes	Note: The expected phenotype(s) may be observed in the above-mentioned mice that bred with Wap-cre mice.

Reference	MGI:2177237 Shakya R, Szabolcs M, McCarthy E, Ospina E, Basso K, Nandula S, Murty V, Baer R, Ludwig T, The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7040-5

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