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Home / Primary Antibodies

AKT1 Antibody (V3797)

SKU : BHA17114830

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NSJ Bioreagents

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Mfr.No.	V3797, V3797-20UG, V3797-100UG
Antigen	AKT1
Clonality	Monoclonal
Description	The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB-beta or RacPK-beta) and Akt 3 (also designated PKB-gamma or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a Pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-beta tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Mouse
Immunogen Region	A portion of amino acids 85-189 from the human protein was used as the immunogen for the AKT1 antibody.
Isotype	IgG2b,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No
Subcellular Location	Nucleus, plasma membrane, cytoplasm

Uniprot	P31749
Clone No	AKT1/2491

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	Store the AKT1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P, WB
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT,Western blot: 1-2ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17114830-1	V3797-20UG	20ug	$219		Add to Cart
BHA17114830-2	V3797-100UG	100ug	$499		Add to Cart

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