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Integrated AAV Offerings: From Cutting-Edge Products to Advanced Custom Services
Overcoming AAV Technology Challenges with Expertly Tailored Vector Design and Production
High-quality AAV Reference Particles
In gene therapy research and development, the availability of well-characterized AAV reference materials is critical for ensuring consistency, reliability, and regulatory compliance. Both researchers and regulators, such as the FDA, emphasize the importance of using standardized AAV reference materials to achieve accurate and reproducible results. AAVnerGene provides two types of high-quality AAV reference materials: full particles and empty particles, each serving distinct roles in AAV-based studies.
AAV Standards (Full) Particles are essential reference materials for qPCR-based vector genome quantification. These particles help to provide precise genome titers, well-defined full-to-empty capsid ratios, and accurate capsid titers. Such thorough characterization is vital for standardizing measurements across different experiments, ensuring data consistency, and supporting reliable outcomes in gene therapy and other AAV research applications. All full AAV reference particles are produced using AAVnerGene's unique and consistent AAVone production system, ensuring high quality and reproducibility.
In addition, AAV Empty Particles are versatile tools that play a crucial role in AAV-based gene therapy development, quality control, and fundamental research. AAVnerGene offers two types of empty particles: AAV Standards (Truly-Empty) Particles and AAV Standards (Byproduct-Empty) Particles. These well-defined empty particles are invaluable for various applications, including evaluating vector purity, optimizing production processes, and understanding the biology of AAV vectors. With these comprehensive AAV reference materials, researchers can achieve greater accuracy and confidence in their studies, advancing the field of gene therapy and beyond.
AAV Standard References List
| AAV Standard References | Capsid | Genome | Production Methods |
| AAV Standards (Full) Particles | Regular VP1,VP2,VP3 | AAV-CMV-EGFP-WPRE-hGHpolyA | |
| AAV Standards (Truly-Empty) Particles | Regular VP1,VP2,VP3 | No genome | |
| AAV Standards (Byproduct-Empty) Particles | Regular VP1,VP2,VP3 | Partial genomes | AAVone system |
Buy AAV Standard References
AAV Standards (Full) Particles
AAV Full Particles as AAV standards and references, which carrying a 2.8 kb AAV-CMV-EGFP-WPRE-hGHpA genome
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AAV Standards (Truly-Empty) Particles
AAV Standards (Truly-Empty) Particles are intentionally created through a specialized production process that includes only the necessary components for AAV replication (e.g., mini-pHelper-AAV2). They contain no genetic material, resulting in completely empty capsids that lack the therapeutic transgene typically present in AAV vectors.
Contact UsAAV Standards (Byproduct-Empty) Particles
AAV Standards (Byproduct-Empty) Particles are unintentional byproducts of the standard AAV vector production process. They are not deliberately generated and may contain partial or incomplete genomes. The key distinction between these two types of empty particles lies in their intentional generation and genetic content, which may potentially affect the purity and function of the final vector.
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AAV Vector Design & Cloning
Expert consultation, design, gene synthesis, and cloning of custom AAV vectors tailored to your research needs.
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Reliable, affordable, and fully customizable AAV packaging service with diverse serotype options and high titer.
Learn moreAAV QC & Characterization
Comprehensive quality control assays including qPCR, SDS-PAGE, mass photometry, and next-generation sequencing.
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