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Anti-CDKL1 Antibody BHA11301112
Alternative: Cyclin-dependent kinase-like 1|Protein kinase p42 KKIALRE|Serine/threonine-protein kinase KKIALRE|CDKL1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 14q21.3
Immunogen: Synthetic peptide, corresponding to amino acids 270-320 of Human KKIALRE.
Description: The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
TARGETWeight: 42 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: KKIALRE (N301) polyclonal antibody detects endogenous levels of KKIALRE protein.
Description: Western blot (WB) analysis of KKIALRE (N301) pAb at 1:500 dilutionLane1:Hela whole cell lysate(40ug)Lane2:H9C2 whole cell lysate(40ug)Lane3:MEF whole cell lysate(40ug)