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Anti-ADARB1 Antibody BHA11301111
Alternative: ADARB1|RNA-editing deaminase 1|ADAR2|DRADA2|RED1|dsRNA adenosine deaminase|Double-stranded RNA-specific editase 1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 21q22.3
Immunogen: Synthetic peptide, corresponding to amino acids 480-530 of Human ADAR2.
Description: ADAR2, also designated adenosine deaminase, RNA-specific (RED1), RNA-editing enzyme 1, DRABA2, DRADA2, ADAR2α-L1, ADAR2α-L2 and ADAR2α-L3, mediates RNA editing by destabilizing RNA through deamination of adenosine to inosine. ADAR2 is responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. It can modify its own pre-mRNA and generate new splice sites. Translocation of endogenous ADAR2 from the nucleolus to the nucleoplasm results in increased editing of endogenous ADAR2 substrates. Alternative splicing of this gene results in several transcript variants that may influence RNA editing. RNA editing involves the deamination of adenosines at specific sites, the result of which can be a change in the amino acid sequence of the protein so that it differs from that predicted by the sequence of the DNA.
TARGETWeight: 82 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: ADAR2 (R510) polyclonal antibody detects endogenous levels of ADAR2 protein.
Description: Western blot (WB) analysis of ADAR2 (R510) pAb at 1:1000 dilutionLane1:L02 whole cell lysate(20ug)Lane2:H9C2 whole cell lysate(40ug)Lane3:CT26 whole cell lysate(40ug)Lane4:MEF whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of ADAR2 (R510) pAb in paraffin-embedded human colon carcinoma tissue at 1:50,showing cytoplasm and nuclear staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Description: Immunohistochemistry (IHC) analyzes of ADAR2 (R510) pAb in paraffin-embedded human lung carcinoma tissue at 1:50,showing cytoplasm and nuclear staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.