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Anti-CBX5 Antibody BHA11301085
Alternative: Chromobox protein homolog 5|Antigen p25|Heterochromatin protein 1 homolog alpha|HP1 alpha|HP1α|CBX5|HP1A
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 12q13.13
Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human CBX5.
Description: Heterochromatin protein 1 (HP1) is a family of heterochromatic adaptor molecules involved in both gene silencing and higher order chromatin structure. All three HP1 family members (α, β, and γ) are primarily associated with centromeric heterochromatin; however, HP1β and γ also localize to euchromatic sites in the genome. HP1 proteins are approximately 25 kDa in size and contain a conserved amino-terminal chromodomain, followed by a variable hinge region and a conserved carboxy-terminal chromoshadow domain. The chromodomain facilitates binding to histone H3 tri-methylated at Lys9, a histone "mark" closely associated with centromeric heterochromatin.
TARGETWeight: 25 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: CBX5 (K69) polyclonal antibody detects endogenous levels of CBX5 protein.
Description: Western blot (WB) analysis of CBX5 (K69) pAb at 1:500 dilutionLane1:MEF whole cell lysate(40ug)Lane2:C6 whole cell lysate(40ug)Lane3:K562 whole cell lysate(40ug)Lane4:Hela whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of CBX5 (K69) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.