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Anti-STAT1 Antibody BHA11301080
Alternative: Signal transducer and activator of transcription 1-alpha/beta|Transcription factor ISGF-3 components p91/p84|STAT1|STAT1α|STAT1β
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 2q32.2
Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human Stat1.
Description: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
TARGETWeight: 87 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: Stat1 (L177) polyclonal antibody detects endogenous levels of Stat1 protein.
Description: Western blot (WB) analysis of Stat1 (L177) polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate
Description: Western blot (WB) analysis of Stat1 (L177) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate(40ug)Lane2:MCF-7 whole cell lysate(40ug)Lane3:A549 whole cell lysate(40ug)Lane4:HepG2 whole cell lysate(40ug)Lane5:The Kidney tissue lysate of Mouse(40ug)Lane6:C6 whole cell lysate(40ug)Lane7:H9C2 whole cell lysate(40ug)