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Anti-TCF7 Antibody BHA11301073
Alternative: Transcription factor 7|TCF-7|T-cell-specific transcription factor 1|T-cell factor 1|TCF-1|TCF7|TCF1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 5q31.1
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human TCF-1.
Description: T-cell factor-1 (TCF-1) is a DNA-binding transcriptional activator that isessential for lymphoid cell development. The TCF family of transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. Several alternative splice variants of TCF-1 have been identified, including TCF-1A, which share a conserved amino terminus and differ in the carboxy terminal sequences. The Wnt mediated signaling pathway induces cytosolic β-catenin binding to TCF proteins within the nucleus, leading to the enhanced expression of the Wnt target genes. The β-catenin-TCF complexes are negatively regulated by the adenomatous polyposis coli (APC) tumor suppressor protein, which phosphorylates β-catenin and, in turn, increases the degradation of cytosolic β-catenin and inhibits the transcriptional activity of the TCF proteins.
TARGETWeight: 42 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: TCF-1 (F26) polyclonal antibody detects endogenous levels of TCF-1 protein.
Description: Western blot (WB) analysis of TCF-1 (F26) pAb at 1:500 dilutionLane1:K562 whole cell lysate(40ug)Lane2:A549 whole cell lysate(40ug)Lane3:U-87MG whole cell lysate(40ug)Lane4:C6 whole cell lysate(40ug)Lane5:MEF whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of TCF-1 (F26) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.