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Anti-TNFRSF1B Antibody BHA11301040
Alternative: Tumor necrosis factor receptor superfamily member 1B|Tumor necrosis factor receptor 2|TNF-R2|Tumor necrosis factor receptor type II|TNF-RII|TNFR-II|p75|p80 TNF-alpha receptor|CD120b|INN=Etanercept|Tumor necrosis factor receptor superfamily member 1b, membrane form|Tumor necrosis factor-binding protein 2|TBP-2|TBPII|TNFRSF1B|TNFBR|TNFR2
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 1p36.22
Immunogen: Synthetic peptide, corresponding to amino acids 390-440 of Human TNF-R2.
Description: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
TARGETWeight: 48 to 73 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: TNF-R2 (P412) polyclonal antibody detects endogenous levels of TNF-R2 protein.
Description: Immunohistochemistry (IHC) analyzes of TNF-R2 (P412) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.