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Anti-TP53 Antibody BHA11301006
Alternative: Cellular tumor antigen p53|Antigen NY-CO-13|Phosphoprotein p53|Tumor suppressor p53|TP53|P53
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 17p13.1
Immunogen: Synthetic peptide, corresponding to amino acids 301-350 of Human p53.
Description: p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.
TARGETWeight: 53 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: p53 (L330) polyclonal antibody detects endogenous levels of p53 protein.
Description: Western blot (WB) analysis of p53 (L330) pAb at 1:500 dilutionLane1:A549 whole cell lysate(40ug)Lane2:MCF-7 whole cell lysate(40ug)Lane3:The Lung tissue lysate of Rat(20ug)Lane4:The Testis tissue lysate of Mouse(40ug)
Description: Immunohistochemistry (IHC) analyzes of p53 (L330) pAb in paraffin-embedded human brain carcinoma tissue at 1:50.