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Anti-BID Antibody BHA11300936
Alternative: BH3-interacting domain death agonist|p22 BID|BID|BH3-interacting domain death agonist p15|p15 BID|BH3-interacting domain death agonist p13|p13 BID|,BH3-interacting domain death agonist p11|p11 BID|BID
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 22q11.21
Immunogen: Synthetic peptide, corresponding to amino acids 50-100 of Human BID.
Description: BID, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.
TARGETWeight: 22 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: BID (I72) polyclonal antibody detects endogenous levels of BID protein.
Description: Western blot (WB) analysis of BID (I72) polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:NIH-3T3 cell lysateLane3:H9C2 cell lysate
Description: Immunohistochemistry (IHC) analyzes of BID (I72) pAb in paraffin-embedded human brain tissue.