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Anti-NPM1 Antibody BHA11300925
Alternative: Nucleophosmin|Nucleolar phosphoprotein B23|Nucleolar protein NO38|Numatrin|NPM1|NPM
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 5q35.1
Immunogen: Synthetic peptide, corresponding to amino acids 201-250 of Human NPM1.
Description: Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
TARGETWeight: 38 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: NPM (K230) polyclonal antibody detects endogenous levels of NPM protein.
Description: Immunohistochemistry (IHC) analyzes of NPM (K230) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.