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Anti-PAK1 Antibody BHA11300924
Alternative: Serine/threonine-protein kinase PAK 1|Alpha-PAK|p21-activated kinase 1|PAK-1|p65-PAK|PAK1|PAKα
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 11q13.5-q14.1
Immunogen: Synthetic peptide, corresponding to amino acids 180-230 of Human PAK1.
Description: Three isoforms of serine/threonine kinases, designated αPAK p68, βPAK p65 and γPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiae kinase Ste 20, involved in pheromone signaling. The α, β and γPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on γPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with γPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TARGETWeight: 60 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: PAK1 (E195) polyclonal antibody detects endogenous levels of PAK1 protein.
Description: Immunohistochemistry (IHC) analyzes of PAK1 (E195) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.