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Anti-ERBB4 Antibody BHA11300920
Alternative: 4ICD|Avian erythroblastic leukemia viral oncogene homolog 4|Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4|E4ICD|EC 220.127.116.11|ErbB4|ERBB4 intracellular domain|ERBB4|HER 4|HER4|Mer4|MGC138404|Oncogene ERBB4|P180erbB4|Proto-oncogene-like protein c-ErbB-4|Receptor protein tyrosine kinase erbB 4 precursor|Receptor tyrosine protein kinase erbB 4|s80HER4|Tyrosine kinase type cell surface receptor HER4|Tyrosine kinase-type cell surface receptor HER4|v erb a avi
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 2q34
Immunogen: Synthetic peptide, corresponding to amino acids 1246-1310 of Human ErbB-4.
Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
TARGETWeight: 150 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: ErbB-4 (E1280) polyclonal antibody detects endogenous levels of ErbB-4 protein.
Description: Immunohistochemistry (IHC) analyzes of ErbB-4 (E1280) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.