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Anti-EGFR Antibody BHA11300919
Alternative: Epidermal growth factor receptor|EC=22.214.171.124|Proto-oncogene c-ErbB-1|Receptor tyrosine-protein kinase erbB-1|ERBB|ERBB1|HER1|EGFR
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 7p11.2
Immunogen: Synthetic peptide, corresponding to amino acids 1041-1090 of Human EGFR.
Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Ligand binding promotes the internalization of EGFR via Clathrin-coated pits and its subsequent degradation in response to its intrinsic tyrosine kinase. EGFR is involved in organ morphogenesis and maintenance and repair of tissues, but upregulation of EGFR is associated with tumor progression. The oncogenic effects of EGFR include initiation of DNA synthesis, enhanced cell growth, invasion and metastasis. Abrogation of EGFR results in cell cycle arrest, apoptosis or dedifferentiation of cancer cells, suggesting that EGFR may be an effective therapeutic target.
TARGETWeight: 175 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: EGFR (F1065) polyclonal antibody detects endogenous levels of EGFR protein.
Description: Western blot (WB) analysis of EGFR (F1065) polyclonal antibody at 1:500 dilutionLane1:H9C2 whole cell lysate(40ug)Lane2:NIH-3T3 whole cell lysate(40ug)Lane3:DLD whole cell lysate(40ug)