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Anti-RB1 Antibody BHA11300916
Alternative: Retinoblastoma-associated protein|p105-Rb|pRb|Rb|pp110|RB1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 13q14.2
Immunogen: Synthetic peptide, corresponding to amino acids 771-820 of Human Rb.
Description: The retinoblastoma tumor suppressor gene product, known as Rb or pRb, regulates differentiation, apoptosis and cell cycle control by coordinating the cell cycle, at G1/S, with transcriptional machinery that includes the heterodimeric E2F family. During G1, cyclin D (D1, 2, 3)-dependent kinase-mediated phosphorylation of Rb at Ser 795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues, including Ser 249/Thr 252, Thr 373, Thr 356, Ser 780, Ser 807/Ser 811 and Thr 821/Thr 826.
TARGETWeight: 89, 106 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Rb (S807) polyclonal antibody detects endogenous levels of Rb protein.
Description: Immunohistochemistry (IHC) analyzes of Rb (S807) pAb in paraffin-embedded human thyroid gland tissue.
Description: Western blot (WB) analysis of Rb (S807) pAb at 1:500 dilutionLane1:SGC7901 whole cell lysate(40ug)Lane2:U-87MG whole cell lysate(40ug)Lane3:SK-OVCAR3 whole cell lysate(40ug)