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Anti-PLCB3 Antibody BHA11300912
Alternative: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase β-3|Phosphoinositide phospholipase C-β-3|Phospholipase C-β-3|PLC-β3|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3|Phosphoinositide phospholipase C-beta-3|Phospholipase C-beta-3|PLC-beta-3|PLCB3|PLCβ3
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 11q13.1
Immunogen: Synthetic peptide, corresponding to amino acids 500-550 of Human PLC β3.
Description: A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2) with molecular weights ranging from 85 to 150 kDa. The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the α subunits of the Gq class of heterotrimeric G proteins and by certain βγ G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are as yet not resolved.
TARGETWeight: 150 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: PLC β3 (L532) polyclonal antibody detects endogenous levels of PLC β3 protein.
Description: Immunohistochemistry (IHC) analyzes of PLC β3 (L532) pAb in paraffin-embedded human breast carcinoma tissue.