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Anti-STK11 Antibody BHA11300911
Alternative: Serine/threonine-protein kinase STK11|Liver kinase B1|LKB1|hLKB1|Renal carcinoma antigen NY-REN-19|STK11|LKB1|PJS
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 19p13.3
Immunogen: Synthetic peptide, corresponding to amino acids 396-442 of Human LKB1.
Description: LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.
TARGETWeight: 48, 54 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: LKB1 (R425) polyclonal antibody detects endogenous levels of LKB1 protein.
Description: Immunohistochemistry (IHC) analyzes of LKB1 (R425) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.