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Anti-VDR Antibody BHA11300902
Alternative: Vitamin D3 receptor|VDR|1,25-dihydroxyvitamin D3 receptor|Nuclear receptor subfamily 1 group I member 1|NR1I1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 12q13.11
Immunogen: Synthetic peptide, corresponding to amino acids 161-210 of Human VDR.
Description: The vitamin D receptor (VDR), also known as the calcitriol receptor, and also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.
TARGETWeight: 43, 55 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: VDR (N204) polyclonal antibody detects endogenous levels of VDR protein
Description: Western blot (WB) analysis of VDR (N204) pAb at 1:500 dilutionLane1:K562 whole cell lysate(40ug)Lane2:HCT116 whole cell lysate(40ug)Lane3:3T3-L1 whole cell lysate(40ug)Lane4:The Kidney tissue lysate of Rat(40ug)
Description: Immunohistochemistry (IHC) analyzes of VDR (N204) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.