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Anti-GRB10 Antibody BHA11300881
Alternative: Growth factor receptor-bound protein 10|GRB10 adapter protein|Insulin receptor-binding protein Grb-IR|GRB10|GRBIR|KIAA0207
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 7p12.1
Immunogen: Synthetic peptide, corresponding to amino acids 32-84 of Human GRB10.
Description: GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
TARGETWeight: 60 to 67 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: GRB10 (L63) polyclonal antibody detects endogenous levels of GRB10 protein.
Description: Immunohistochemistry (IHC) analyzes of GRB10 (L63) pAb in paraffin-embedded human brain carcinoma tissue at 1:50.